Testicular Cell Junction: A Novel Target for Male Contraception
نویسندگان
چکیده
منابع مشابه
Novel epididymal proteins as targets for the development of post-testicular male contraception.
Apart from condoms and vasectomy, modern contraceptive methods for men are still not available. Besides hormonal approaches to stop testicular sperm production, the post-meiotic blockage of epididymal sperm maturation carries lots of promise. Microarray and proteomics techniques and libraries of expressed sequence tags, in combination with digital differential display tools and publicly availab...
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Urokinase-type plasminogen activator (uPA) is closely related to male reproduction. With the aim of investigating the possibility for uPA as a potential contraceptive target, in the present work, Kunming male mice were immunized by human uPA subcutaneous injection at three separate doses for 3 times. Then the potency of the anti-human uPA antibody in serum was analyzed, and mouse fertility was ...
متن کاملGene knockouts that affect male fertility: novel targets for contraception.
There is an urgent need for a better method of contraception that is accepted, effective, and available, due the population explosion and unintended pregnancy. Various targets are being investigated that can be used for contraception. The ideal target should be non-steroidal, intercourse-independent, non-surgical, reversible, and non-barrier with no side effects. The gene knockout technology is...
متن کاملMale Contraception
Very few options for men to initiate fertility control are currently available. Due to the potential public health impact of a novel method of contraception for men in the developed and developing world, a number of organizations are conducting or supporting studies which focus on the male contraceptive aspect of reproductive health. These include bilateral and multilateral donors, national gov...
متن کامل[Male contraception].
Clear evidence shows that many men and women would welcome new male methods of contraception, but none have become available. The hormonal approach is based on suppression of gonadotropins and thus of testicular function and spermatogenesis, and has been investigated for several decades. This approach can achieve sufficient suppression of spermatogenesis for effective contraception in most men,...
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ژورنال
عنوان ژورنال: Current Medicinal Chemistry
سال: 2009
ISSN: 0929-8673
DOI: 10.2174/092986709787549262